LINKER: a program to generate linker sequences for fusion proteins
نویسندگان
چکیده
منابع مشابه
LINKER: a program to generate linker sequences for fusion proteins.
The construction of functional fusion proteins often requires a linker sequence that adopts an extended conformation to allow for maximal flexibility. Linker sequences are generally selected based on intuition. Without a reliable selection criterion, the design of such linkers is often difficult, particularly in situations where longer linker sequences are required. Here we describe a program c...
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LINKER was developed as an online server to assist biomedical researchers to design linker sequences for constructing functional fusion proteins. The program automatically generates a set of peptide sequences that are known to adopt extended conformations as determined by X-ray crystallography and NMR. In addition to the desired linker sequence length, the web interface provides a number of opt...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 2000
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/13.5.309